Press releases - Article | Friedrich Miescher Institute
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چکیده
Trans-acting small interfering RNAs (siRNAs) trigger a digital silencing response in Paf1C mutant fission yeast cells. Shown here are individual fission yeast colonies that present two different phenotypes (white or red), although all cells are genetically identical. Cells turn red upon siRNA-directed assembly of heterochromatin at the ade6+ gene. Variegating colonies indicate that descendants of the founder cell stochastically switched the ade6+ expression state in the course of the experiment. Since the gained silencing or reactivation of ade6+ is stably maintained over mitotic divisions, the colonies are mixed to different degrees depending on when the switch occurred (For details, see Shimada et al.) December 22, 2016
منابع مشابه
Two Catalytic Domains Are Required for Protein
Received for publication, June 8, 2005, and in revised form, November 3, 2005 Published, JBC Papers in Press, November 6, 2005, DOI 10.1074/jbc.C500241200 Yu Zhang, Benoit Gilquin, Saadi Khochbin, and Patrick Matthias From the Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, P. O. Box 2543, Maulbeerstrasse 66, 4058 Basel, Switzerland and the INSERM U309, Insti...
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OBJECTIVE To determine whether the quality of press releases issued by medical journals can influence the quality of associated newspaper stories. DESIGN Retrospective cohort study of medical journal press releases and associated news stories. SETTING We reviewed consecutive issues (going backwards from January 2009) of five major medical journals (Annals of Internal Medicine, BMJ, Journal ...
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Plant Molecular and Cellular Genetics, Bose Institute, P-1/12, C.I.T. Scheme, VII-M, Calcutta700054, India. Protein and Peptide Analytics Laboratory, Friedrich Miescher Institut for Biomedical Research, P.O. Box 2543, CH-4002 Basel, Switzerland. Distributive Information Center, Bose Institute, P-1/12, C.I.T. Scheme, VII-M, Calcutta700054, India. For Correspondence (Phone: 91(033) 23379544; FAX:...
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Like many success stories, the career of DNA as the molecule of heredity and icon of modern biology began under somewhat less glamorous circumstances. The story begins in 1844, one hundred years before Avery and his colleagues realised the significance of DNA as the genetic material (see accompanying article), with the birth in Basel of Friedrich Miescher, who went on to discover DNA at the age...
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BACKGROUND Previous studies indicate that in published reports, trial results can be distorted by the use of "spin" (specific reporting strategies, intentional or unintentional, emphasizing the beneficial effect of the experimental treatment). We aimed to (1) evaluate the presence of "spin" in press releases and associated media coverage; and (2) evaluate whether findings of randomized controll...
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